Publications on mice from labs in the Cleveland area in last 2 weeks

Published Transgenic And Knockout Mice Made in Our Facility

2009:
  1. Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO and Roth BL. Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors. Neuron 2009 63(1):27-39

    2. • The Roth lab developed transgenic mice in which activity of specific neuronal populations can be increased by a peripherally administered ligand. This approach is a powerful new tool to study mammalian brain function.

  2. Kawanami A, Matsushita T, Chan YY, Murakami S. Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum. Biochem Biophys Res Commun. 2009

  3. Soler DC, Kadunganattil S, Ramdas S, Myers K, Roca J, Slaughter T, Pilder SH, and Vijayaraghavan S Expression of Transgenic PPP1CC2 in the Testis of Ppp1cc-Null Mice Rescues Spermatid Viability and Spermiation but Does Not Restore Normal Sperm Tail Ultrastructure, Sperm Motility, or Fertility Biol Reprod 2009

  4. Mailankot M, Staniszewska MM, Butler H, Caprara MH, Howell S, Wang B, Doller C, Reneker LW, Nagaraj RH. Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. Lab Invest. 2009 89(5):498-512

  5. Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet. 2009 18(8):1395-404

  6. Cheng L, Pilder S, Nairn AC, Ramdas S, Vijayaraghavan S. PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related. PLoS One. 2009;4(3):e4861

  7. Li H, Wang D, Singh LS, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 2009 4(5):e5705.

  8. Walker MP, Tian L, Matera AG. PLoS One. Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. 2009 4(7):e6171.

  9. Matsushita T, Wilcox WR, Chan YY, Kawanami A, Bükülmez H, Balmes G, Krejci P, Mekikian PB, Otani K, Yamaura I, Warman ML, Givol D, Murakami S. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet. 2009 18(2):227-240

  10. Mack JA, Maytin EV. Persistent Inflammation and Angiogenesis during Wound Healing in K14-Directed Hoxb13 Transgenic Mice. J Invest Dermatol. 2009

  11. Zhang T, Yong SL, Drinko JK, Popovic ZB, Shryock JC, Belardinelli L, Wang QK. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. Int J Cardiol. 2009

  12. Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci U S A. 2009

  13. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2009

  14. Qing Li, Danping Huang, Kristine Nacion, Hong Bu and Feng Lin Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis Mol Immunol. 2009 46(15):2885-91.

  15. Takehiko Matsushita, Yuk Yu Chan, Aya Kawanami, Gener Balmes, Gary E. Landreth, and Shunichi Murakami ERK1 and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis Mol Cell Biol. 2009 29(21):5843-57

  16. Bliss SP; Miller A; Navratil AM; Xie J; McDonough SP; Fisher PJ; Landreth GE; Roberson MS, ERK signaling in the pituitary is required for female but not male fertility., Mol Endocrinol 2009 Jul;23(7):1092-101

  17. Nakamura Y, Cui Y, Fernando C, Kutz WE, Warman ML. Normal growth and development in mice over-expressing the CCN family member WISP3. J Cell Commun Signal. 2009 3(2):105-13


2008:
  1. Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci U S A. 2008 105(44):17115-20

  2. Lerch-Haner JK, Frierson D, Crawford LK, Beck SG, Deneris ES. Serotonergic transcriptional programming determines maternal behavior and offspring survival. Nat Neurosci. 2008 (9):1001-3.

    3. • The Deneris lab investigated the maternal behavior of mice mutant for Pet1. These mice are deficient in brain serotonin neurons. They used different BAC transgenes expressing the human gene at different levels to rescue maternal behavior to different degrees.

  3. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 47(50):13296-307.

  4. Ogba N, Chaplin LJ, Doughman YQ, Fujinaga K, Montano MM. HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res. 2008 68(17):7015-24.

  5. Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N, Zhou Q, Ward NL, Watanabe M. Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 102(4):415-22.

  6. Krueger KC, Deneris ES. Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors. J Neurosci. 2008 28(48):12748-58.

  7. Sutton AL, Zhang X, Dowd DR, Kharode YP, Komm BS, Macdonald PN. Semaphorin 3B Is a 1,25-Dihydroxyvitamin D3-Induced Gene in Osteoblasts that Promotes Osteoclastogenesis and Induces Osteopenia in Mice. Molecular Endocrinology 2008 22 (6): 1370-1381

  8. Hodges CA, Cotton CU, Palmert MR, Drumm ML. Generation of a conditional null allele for Cftr in mice. Genesis. 2008 46(10):546-52.

  9. Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD, Saitta SC, Landreth GE. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 28(27):6983-95.

  10. Merkulov S, Zhang WM, Komar AA, Schmaier AH, Barnes E, Zhou Y, Lu X, Iwaki T, Castellino FJ, Luo G, McCrae KR. Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood. 2008 111(3):1274-81.

  11. Huang QQ, Feng HZ, Liu J, Du J, Stull LB, Moravec CS, Huang X, Jin JP. Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function. Am J Physiol Cell Physiol. 2008 294(1):C213-22.

  12. Yang X, Zhou Y, Barcarse EA, O'Gorman S. Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol. 2008 314(1):171-88.

  13. Hu Y, Lu X, Zhou G, Barnes EL, Luo G. Recql5 Plays an Important Role in DNA Replication and Cell Survival Following Camptothecin Treatment. Mol Biol Cell. 2008 (1):114-23

  14. Dy, P., Y. Han, and V. Lefebvre. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46:294-299

  15. Han Y, Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol. 2008 28(16):4999-5013

  16. Mailankot M, Smith D, Howell S, Wang B, Jacobberger JW, Stefan T, Nagaraj RH. Cell cycle arrest by kynurenine in lens epithelial cells. Invest Ophthalmol Vis Sci. 2008 49(12):5466-75

  17. Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK, O'Gorman S. Pbx3 is required for normal locomotion and dorsal horn development. Dev Biol. 2008 314(1):23-39

2007:
  1. Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 2007 21(23):3073-84.

    2. • The Luo laboratory demonstrated that mice mutant for Recql5 are susceptible to cancer, and determined the mechanism by which Recql5 suppresses homologous recombination.

  2. Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007 282(45):32844-55.

    3. • The Hanson laboratory showed that overexpression of PEPCK in muscle dramatically changes energy metabolism in mice, resulting in leaner, more athletic mice. While these mice made a splash in the popular press for their athletic prowess, they will be important tools in understanding the links between metabolism, energy expenditure and cancer.
    • Youtube Video

  3. Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 46(28):8350-9.

  4. Penzo-Mendez A, Dy P, Pallavi B, Lefebvre V. Generation of mice harboring a Sox4 conditional null allele. Genesis. 2007 45(12):776-80.

  5. Johnson MT, Freeman EA, Gardner DK, Hunt PA. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod. 2007 77(1):2-8.

  6. Zhang T, Yong SL, Tian XL, Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochem Biophys Res Commun. 2007 355(2):444-50

  7. Jenkins MW, Patel P, Deng H, Montano MM, Watanabe M, Rollins AM. Phenotyping transgenic embryonic murine hearts using optical coherence tomography. Appl Opt. 2007 46(10):1776-81.

  8. Wu L, Archacki SR, Zhang T, Wang QK. Induction of high STAT1 expression in transgenic mice with LQTS and heart failure. Biochem Biophys Res Commun. 2007 358(2):449-54

2006:
  1. Xu X, Scott MM, Deneris ES. Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes. Mol Cell Biol. 2006 (15):5636-49

    2. • The Deneris lab used recombineered PAC transgenes to deduce the regulatory logic of cis-acting sequences in the nicotinic receptor gene cluster, demonstrating that there are shared regulatory elements.

  2. Jiang S, Xia D, Samols D. Expression of rabbit C-reactive protein in transgenic mice inhibits development of antigen-induced arthritis. Scand J Rheumatol. 2006 35(5):351-5.

  3. LaFauci G, Carp RI, Meeker HC, Ye X, Kim JI, Natelli M, Cedeno M, Petersen RB, Kascsak R, Rubenstein R. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. J Gen Virol. 2006 87(Pt 12):3773-80.

  4. Crish JF, Gopalakrishnan R, Bone F, Gilliam AC, Eckert RL. The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol. 2006 126(2):305-14.

  5. Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006 281(33):23698-711

  6. Basu A, DuBois G, Haldar S. Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. Front Biosci. 2006 11:1508-21

2005:
  1. Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 435(7040):360-4.

    2. • The Ter mutation in mice causes germ cell loss and testicular germ cell tumors. The characterization of the Ter phenotype and the identification of Dnd as the gene mutant in Ter by the Nadeau and Matin labs was supported by services provided by the core. Transgenic mice expressing Green Fluorescent Protein from a germ cell specific promoter (Oct4-GFP) constructed by the facility demonstrated that germ cells are fewer in the Ter mutants. Dnd was identified positively as the gene mutant in Ter by complementation of germ cell numbers with a Dnd transgene introduced into mice by the facility.

  2. Scott MM, Wylie CJ, Lerch JK, Murphy R, Lobur K, Herlitze S, Jiang W, Conlon RA, Strowbridge BW, Deneris ES. A genetic approach to access serotonin neurons for in vivo and in vitro studies. Proc Natl Acad Sci U S A. 2005 102(45):16472-7.

    3. • BAC transgene constructs were used by the Deneris lab to rescue the Pet1 mutant phenotype, and to express EYFP and Cre in serotonergic neurons of the brain. These experiments generated genetic reagents for the dissection of the function of brain-derived serotonin and beautifly illustrate the power of BAC transgenes.

  3. Ryan KA, Pimplikar SW Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 171(2):327-35

    4. • The Pimplikar lab used transgene constructs to demonstrate that the intracellular domain of the Alzheimer Precursor Protein (APP) has a functional role, opening investigation of its role in Alzheimer Disease.

  4. Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 2005 30(4):624-9.

  5. Hakimi P, Johnson MT, Yang J, Lepage DF, Conlon RA, Kalhan SC, Reshef L, Tilghman SM, Hanson RW. Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab (Lond). 2005 2:33

  6. Nethery DE, Moore BB, Minowada G, Carroll J, Faress JA, Kern JA. Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. J Appl Physiol. 2005 99(1):298-307

  7. Black S, Wilson A, Samols D. An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. J Immunol. 2005 175(2):1192-6.

  8. O'Gorman S. Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice. Dev Dyn. 2005 234(1):124-31.

  9. Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G. Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol. 2005 25(9):3431-42

  10. Chan SA, Polo-Parada L, Landmesser LT, Smith C. Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice. J Neurophysiol. 2005 94(2):1037-47

  11. Scott MM, Krueger KC, Deneris ES A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. J Neurosci. 2005 25(10):2628-36

  12. Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, Luo G Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet. 2005 14(6):813-25

  13. Kutz WE, Gong Y, Warman ML. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 25(1):414-21

  14. Adhikary G, Crish JF, Bone F, Gopalakrishnan R, Lass J, Eckert RL. An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo. Invest Ophthalmol Vis Sci 2005 46:1219-1227.

  15. Adhikary G, Crish JF, Gopalakrishnan R, Bone F, Eckert RL. Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors. Invest Ophthalmol Vis Sci 2005 46: 3109-3120.

  16. Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, Forsthuber TG. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol. 2005 175(4):2374-80

  17. Clement-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssi¸re B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A. 2005 102(48):17406-11

2004:
  1. Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004 165:145-154

    2. • The Lemmon lab used L1 knockout mice to study the role of this homophilic adhesion molecule in brain development.

  2. Nosek TM, Brotto MA, Jin JP. Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis. Arch Biochem Biophys. 2004 430(2):178-84.

  3. Polo-Parada L, Bose CM, Plattner F, Landmesser LT. Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice. J Neurosci. 2004 24(8):1852-64.

  4. Adhikary G, Crish J, Lass J, Eckert RL. Regulation of involucrin expression in normal human corneal epithelial cells: a role for activator protein one. Invest Ophthalmol Vis Sci 2004 45:1080-1087

  5. Balasubramanian S, Eckert RL. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. 2004 J Biol Chem 279:24007-24014