Published Mice Generated by the Core


2014
  1. Cerpa V, Gonzalez A, Richerson GB Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception. Neuroscience. 2014 279:65-76.

  2. Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2014 PMID: 25401279

  3. Ng HP, Zhou Y, Song K, Hodges CA, Drumm ML, Wang G. Neutrophil-mediated phagocytic host defense defect in myeloid cftr-inactivated mice. PLoS One. 2014 9(9):e106813. PMID: 25184794

  4. Khoriaty R, Vasievich MP, Jones M, Everett L, Chase J, Tao J, Siemieniak D, Zhang B, Maillard I, Ginsburg D. Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B. Mol Cell Biol. 2014 PMID: 25071156

  5. Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD. Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia. 2014 PMID: 25066805

  6. Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A. MicroRNA 135 Is Essential for Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity. 2014 Neuron. 6273(14)00486-3. PMID: 24952960

  7. Gresham KS, Mamidi R, Stelzer JE. The contribution of cMyBP-C Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. J Physiol. 2014 PMID: 24951619

  8. Hinman MN, Sharma A, Luo G, Lou H. Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons. Mol Cell Biol. 2014 34(12):2188-2197. PMID: 24710274

  9. Arachiche A, de la Fuente M, Nieman MT. Platelet Specific Promoters Are Insufficient to Express Protease Activated Receptor 1 (PAR1) Transgene in Mouse Platelets. PLoS One. 2014 9(5):e97724. PMID: 24830314

  10. Spoida K, Masseck OA, Deneris ES, Herlitze S. Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice. Proc Natl Acad Sci U S A. 2014 PMID: 24733892

  11. Jacobsen CM, Barber LA, Ayturk UM, Roberts HJ, Deal LE, Schwartz MA, Weis M, Eyre D, Zurakowski D, Robling AG, Warman ML. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2014 PMID: 24677211

2013
  1. Ouyang Z, Chen Z, Ishikawa M, Yue X, Kawanami A, Leahy P, Greenfield EM, Murakami S. Prx1 and 3.2kb Col1a1 promoters target distinct bone cell populations in transgenic mice. Bone. 3282(13)00426-2 2013 PMID: 24513582

  2. Ayturk UM, Jacobsen CM, Christodoulou DC, Gorham J, Seidman JG, Seidman CE, Robling AG, Warman ML. An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res. 2013 28(10):2081-93. PMID: 23553928

  3. Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A. 2013 110(15):5852-7. PMID: 23530215

  4. Shi Q, Prior M, Zhou X, Tang X, He W, Hu X, Yan R. Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice. J Neurosci. 2013 33(7):3059-66. PMID: 23407961

  5. Kedlaya R, Veera S, Horan DJ, Moss RE, Ayturk UM, Jacobsen CM, Bowen ME, Paszty C, Warman ML, Robling AG. Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome. Sci Transl Med. 2013 5(211):211ra158. PMID: 24225945

  6. Luo X, He W, Hu X, Yan R. Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice. Biol Psychiatry. 2013 PMID: 24210810

  7. Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM. HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability. Biochem J. 2013 456(2):195-204 PMID: 24015760

  8. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia. Cancer Cell. 2013 PMID: 24183681

  9. Bükülmez H, Khan F, Bartels CF, Murakami S, Ortiz-Lopez A, Sattar A, Haqqi TM, Warman ML. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in an inflammatory arthritis mouse model. Arthritis Rheum. 2013 PMID: 24114569

  10. Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. Recombinant Human Prion Protein Inhibits Prion Propagation in vitro. Sci Rep. 2013 Oct 9;3:2911. PMID: 24105336

  11. Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M. The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell. 2013 PMID: 23933087

  12. Ohta S, Misawa A, Lefebvre V, Okano H, Kawakami Y, Toda M. Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells. PLoS One. 2013 Sep 16;8(9):e74315. PMID: 24066135

  13. Liu L, Li M, Spangler LC, Spear C, Veenstra M, Darnall L, Chang C, Cotleur AC, Ransohoff RM. Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2. Genesis. 2013 PMID: 23650205

  14. DePuy SD, Stornetta RL, Bochorishvili G, Deisseroth K, Witten I, Coates M, Guyenet PG. Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus. J Neurosci. 2013 33(4):1486-97. PMID: 23345223

  15. Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 14:54. PMID: 23773267

  16. He X, Arrotta N, Radhakrishnan D, Wang Y, Romigh T, Eng C. Cowden Syndrome-Related Mutations in PTEN Associate with Enhanced Proteasome Activity. Cancer Res. 2013 73(10):3029-40 PMID: 23475934

  17. Malhotra N, Narayan K, Cho OH, Sylvia KE, Yin C, Melichar H, Rashighi M, Lefebvre V, Harris JE, Berg LJ, Kang J; Immunological Genome Project Consortium. 2013 A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 38(4):681-93. PMID: 23562159

  18. Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. 2013 Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem 288(25):18429-38 PMID: 23649630

  19. Montano MM, Desjardins C, Doughman YQ, Hsieh YH, Hu Y, Bensinger H, Wang C, Stelzer J, Dick T, Hoit B, Chandler MP, Yu X, Watanabe M. (2013) Inducible reexpression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res. PMID: 23585471

  20. Kiyasova V, Bonnavion P, Scotto-Lomassese S, Fabre V, Sahly I, Tronche F, Deneris E, Gaspar P, Fernandez SP. A subpopulation of serotonergic neurons that do not express the 5-HT1A autoreceptor. ACS Chem Neurosci. 2013 4(1):89-95 PMID: 23336048

  21. Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P. Postnatal growth defects in mice with constitutive depletion of central serotonin. ACS Chem Neurosci. 2013 4(1):171-81 PMID: 23336056

  22. Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013 190(5):2080-9. 2013 PMID: 23345330

  23. Mead TJ, Wang Q, Bhattaram P, Dy P, Afelik S, Jensen J, Lefebvre V. A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res. 2013 PMID: 23449223

2012
  1. Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, Sharma N, Liao X, Hale A, Boerboom L, Feaver RE, Gao H, Desai A, Schmaier A, Gerson SL, Wang Y, Atkins GB, Blackman BR, Simon DI, Jain MK. Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest. 2012 122(12):4727-31. PMID: 23160196

  2. Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2012 PMID: 23152540

  3. Zhou W, Chen L, Paul J, Yang S, Li F, Sampson K, Woodgett JR, Beaulieu JM, Gamble KL, Li X. The effects of glycogen synthase kinase-3beta in serotonin neurons. PLoS One. 2012;7(8):e43262. PMID: 22912839

  4. Tao J, Zhu M, Wang H, Afelik S, Vasievich MP, Chen XW, Zhu G, Jensen J, Ginsburg D, Zhang B. SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9 PMID: 22745161

  5. Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP. Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification. Development. 2012 139(23):4428-38. PMID: 23095887

  6. Bonfield TL, Hodges CA, Cotton CU, Drumm ML. Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid-derived cells slows resolution of inflammation and infection. J Leukoc Biol. 2012 92(5):1111-22 PMID: 22859830

  7. Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C. Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain-barrier damage and inflammation. Blood. 2012 PMID: 22936662

  8. Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, Cohen J, Mannangatti P, Jessen T, Thompson BJ, Ye R, Kerr TM, Carneiro AM, Crawley JN, Sanders-Bush E, McMahon DG, Ramamoorthy S, Daws LC, Sutcliffe JS, Blakely RD. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A. 2012 109(14):5469-74. PMID: 22431635

  9. Sinha N, Pilder S, Vijayaraghavan S. Significant Expression Levels of Transgenic PPP1CC2 in Testis and Sperm Are Required to Overcome the Male Infertility Phenotype of Ppp1cc Null Mice. PLoS One. 2012;7(10):e47623 PMID: 23082183

  10. Wang W, Cui Y, Shen J, Jiang J, Chen S, Peng J, Wu Q. (2012) Salt-Sensitive Hypertension and Cardiac Hypertrophy in Transgenic Mice Expressing a Corin Variant Identified in Blacks. Hypertension. PMID: 22987923

  11. Ghosal K, Stathopoulos A, Thomas D, Phenis D, Vitek MP, Pimplikar SW. (2012) The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features. Neurodegener Dis. PMID: 22965147

  12. Ketchart W, Smith KM, Krupka T, Wittmann BM, Hu Y, Rayman PA, Doughman YQ, Albert JM, Bai X, Finke JH, Xu Y, Exner AA, Montano MM. (2012) Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis. Oncogene. PMID: 22964639

  13. Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH. (2012) Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability. Proc Natl Acad Sci U S A.

  14. Seachrist DD, Johnson E, Magee C, Clay CM, Graham JK, Veeramachaneni DN, Keri RA. 2012 Overexpression of Follistatin in the Mouse Epididymis Disrupts Fluid Resorption and Sperm Transit in Testicular Excurrent Ducts. Biol Reprod

  15. Tian H, Lu X, Guo H, Corn D, Molter J, Wang B, Luo G, Lee Z 2012 Radio-deoxynucleoside Analogs used for Imaging tk Expression in a Transgenic Mouse Model of Induced Hepatocellular Carcinoma. Theranostics 2(6):597-606

  16. Kuwahara M, Yamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V, Nakayama T. (2012) The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation. Nat Immunol.

  17. Niziolek PJ, Warman ML, Robling AG (2012) Mechanotransduction in bone tissue: the A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner. Bone

  18. Ishii A, Fyffe-Maricich SL, Furusho M, Miller RH, Bansal R (2012) ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination. J Neurosci. 32(26):8855-64.

  19. Pucilowska J, Puzerey PA, Karlo JC, Galán RF, Landreth GE. (2012) Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes. J Neurosci. 32(25):8663-77.

  20. Fox SR, Deneris ES. (2012) Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. J Neurosci. 32(23):7832-42.

  21. Shim S, Kwan KY, Li M, Lefebvre V and Sestan N (2012) Cis-regulatory control of corticospinal system development and evolution. Nature 486:74-79
    • Sox4 and Sox11 conditional knockouts generated by the Lefebvre lab were used by Shim et al to show that Sox4 and Sox11 are required for specification and connectivity of the corticospinal tract in mice.

  22. Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J. (2012) Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development 139, 1744-1753 PMID: 22461559
    • The Jensen lab delineated the role of Notch signaling in the choice between pancreatic exocrine and endocrine fates with a doxycycline-regulated transgene expressing dominant negative Maml1 and nuclear EGFP.

  23. Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C, and Mayford M (2012) Generation of a Synthetic Memory Trace. Science 335 (6075), 1513-1516.
    • Using a combination of genetic reagents including a transgenic mouse that the core generated for Bryan Roth's lab (Alexander et al., 2009 Neuron 63:27), Garner et al. generate synthetic memories in the brain of a mouse, illuminating the mechanisms of learning and memory.

  24. Heaney JD, Anderson EL, Michelson MV, Zechel JL, Conrad PA, Page DC, Nadeau JH. (2012) Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice. Development 139(9):1577-86 PMID: 22438569

  25. Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q. (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 484(7393):246-50 PMID: 22437503
    • High blood pressure induced in pregnancy, pre-eclampsia, is a serious complication for mother and fetus, but is poorly understood. The Wu lab provides insight into pre-eclampsia by showing that atrial natriuretic peptide-converting enzyme (Corin) and its substrate atrial natriuretic peptide (ANP) are important in trophoblast invasion and spiral artery remodelling. In their absence, pregnant mice developed pre-ecamplsia.

  26. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK (2012) Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483(7387):96-9
    • Heart attacks occur most frequently in the morning and evening. Using Klf15 transgenic and knockout mice, the Jain lab showed that the Klf15 transcription factor regulates circadian changes in heart rhythm, and that deficiency or excess of Klf15 increase susceptibility to arrhythmia.

  27. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, Ballock RT, Lefebvre V (2012) Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes. Dev Cell 22:597-609
    • The Lefebvre laboratory showed that the Sox9 gene is required in the growth plate of bones for the proliferation and hypertrophy of chondrocytes, in addition to its known roles earlier in chondrogenesis.

  28. Espallergues J, Teegarden SL, Veerakumar A, Boulden J, Challis C, Jochems J, Chan M, Petersen T, Deneris E, Matthias P, Hahn CG, Lucki I, Beck SG, Berton O. (2012) HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. J Neurosci. 32(13):4400-16.

  29. Mu L, Berti L, Masserdotti G, Covic M, Michaelidis TM, Doberauer K, Merz K, Rehfeld F, Haslinger A, Wegner M, Sock E, Lefebvre V, Couillard-Despres S, Aigner L, Berninger B, Lie DC.(2012) SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. J Neurosci 32(9):3067-3080

  30. Moriya K, Sakai K, Yan MH, Sakai T (2012) Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury. Hepatology

  31. Kyono A, Avishai N, Ouyang Z, Landreth GE, Murakami S. (2012) FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation. J Bone Miner Metab. 30:19-30

  32. Klokov D, Leskov K, Araki S, Zou Y, Goetz EM, Luo X, Willson D, Boothman DA. (2012) Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGFβ1 signaling to confer a pro-survival bystander effect. Oncogene. 2012

2011
  1. Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS. (2011) Convergence of the insulin and serotonin programs in the pancreatic β-cell. Diabetes. 60(12):3208-16

  2. Deneris ES. (2011) Molecular genetics of mouse serotonin neurons across the lifespan. Neuroscience 197:17-27

  3. Niziolek PJ, Farmer TL, Cui Y, Turner CH, Warman ML, Robling AG. (2011) High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes. Bone

  4. Hodges CA, Grady BR, Mishra K, Cotton CU, Drumm ML. (2011) Cystic fibrosis growth retardation is not correlated with loss of Cftr in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 301(3):G528-36.

  5. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. (2011) Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 32(9):1725-9

  6. Gutierrez DV, Mark MD, Masseck O, Maejima T, Kuckelsberg D, Hyde RA, Krause M, Kruse W, Herlitze S. (2011) Optogenetic Control of Motor Coordination by Gi/o Protein-coupled Vertebrate Rhodopsin in Cerebellar Purkinje Cells. J Biol Chem. 286(29):25848-58.

  7. Szczepanek K, Chen Q, Derecka M, Salloum FN, Zhang Q, Szelag M, Cichy J, Kukreja RC, Dulak J, Lesnefsky EJ, Larner AC. (2011) Mitochondrial-targeted signal transducer and activator of transcription (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species. J Biol Chem. 2011

  8. Depuy SD, Kanbar R, Coates MB, Stornetta RL, Guyenet PG. (2011) Control of breathing by raphe obscurus serotonergic neurons in mice. J Neurosci. 2011 Feb 9;31(6):1981-90.

  9. Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. (2011) A sponge transgenic mouse model reveals important roles for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina. J Biol Chem. 286:31749-60

  10. Cui Y, Niziolek PJ, Macdonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG. (2011) Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91
    • The Warman lab developed mice which carry patient-derived mutations in Lrp5 which recapitulate the increased bone mass seen in these patients. Importantly, they showed that the effect of Lrp5 activity is within the bone, and not indirect through circulating serotonin, as previously suggested.
    • 2 Studies in Conflict on Growth of Bone: New York Times

  11. Berger DS, Moyer M, Kliment GM, van Lunteren E, Ladd AN (2011) Expression of a Dominant Negative CELF Protein In Vivo Leads to Altered Muscle Organization, Fiber Size, and Subtype. PLoS One 6(4):e19274.

  12. Hawthorne AL, Hu H, Kundu B, Steinmetz MP, Wylie CJ, Deneris ES, Silver J. (2011) The Unusual Response of Serotonergic Neurons after CNS Injury: Lack of Axonal Dieback and Enhanced Sprouting within the Inhibitory Environment of the Glial Scar. J Neurosci 31(15):5605-5616.

  13. Song NN, Xiu JB, Huang Y, Chen JY, Zhang L, Gutknecht L, Lesch KP, Li H, Ding YQ. (2011) Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PLoS One. 6(1):e15998.

  14. Kiyasova V, Fernandez SP, Laine J, Stankovski L, Muzerelle A, Doly S, Gaspar P. (2011) A Genetically Defined Morphologically and Functionally Unique Subset of 5-HT Neurons in the Mouse Raphe Nuclei. J Neurosci. 31(8):2756-68.

  15. Liu Y, Jiang Y, Si Y, Kim JY, Chen ZF, Rao Y. (2011) Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature 472, 95-99
    • The Rao laboratory showed that serotonin regulates sexual preference in male mice. They made use of an ePet-Cre transgene from Evan Deneris lab to specifically knockout Lmx1b in the serotonergic neurons of the central nervous system.

  16. Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S. (2011) Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26.

  17. Lu X, Guo H, Molter J, Miao H, Gerber L, Hu Y, Barnes EL, Vogel H, Lee Z, Luo G, Wang B. (2011) Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liver. J Hepatol. 55(1):96-102

  18. Mester JL, Tilot AK, Rybicki LA, Frazier TW 2nd, Eng C. (2011) Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur J Hum Genet. 19(7):763-8

  19. Fyffe-Maricich SL, Karlo JC, Landreth GE, Miller RH. (2011) The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing of Oligodendrocyte Differentiation. J Neurosci 31(3):843-50.

  20. Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD. (2011) Specific Functions for ERK/MAPK Signaling during PNS Development. Neuron 69(1):91-105
    • The Snider laboratory in collaboration with Gary Landreth showed that Erk1/2 kinases are necessary in the neural crest for Schwann cells and peripheral nervous system development.

2010
  1. Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X. (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 32(1):54-66.
    • The Li laboratory showed that SIGIRR, a TLR-IL-1R receptor superfamily member, regulates the differentiation and expansion of Th17 T helper cells. These results have implications for the understanding of autoimmune disease.

  2. Wang Y, Martin JF, Bai CB. (2010) Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 348(2):199-209

  3. Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK. (2010) The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine. Endocr Relat Cancer 17(1):283-91.

  4. Oh E, Maejima T, Liu C, Deneris E, Herlitze S. (2010) Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. J Biol Chem 285(40):30825-36.

  5. Hu Y, Lu X, Luo G (2010) Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice. World J Gastroenterol 16(12):1482-6.

  6. Buchanan GF, Richerson GB (2010) Central serotonin neurons are required for arousal to CO2. Proc Natl Acad Sci U S A. 107(37):16354-9

  7. Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL, Scacheri PC. (2010 CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet. 6(7):e1001023.

  8. Roy D, Gargesha M, Steyer GJ, Hakimi P, Hanson RW, Wilson DL (2010) Multi-scale characterization of the PEPCK-C mouse through 3D cryo-imaging. Int J Biomed Imaging. 2010:105984

  9. Ogba N, Doughman YQ, Chaplin LJ, Hu Y, Gargesha M, Watanabe M, Montano MM. (2010) HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland. Oncogene 29(25):3639-49.

  10. Gangadhariah MH, Mailankot M, Reneker L, Nagaraj RH (2010) Inhibition of methylglyoxal-mediated protein modification in glyoxalase I overexpressing mouse lenses. J Ophthalmol 2010:274317.

  11. Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V. (2010) Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 1:9. doi: 10.1038/ncomms1008.

  12. Mailankot M, Howell S, Nagaraj RH (2010) Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta 1802(7-8):609-20.

  13. Sebastian A, Matsushita T, Kawanami A, Mackem S, Landreth GE, Murakami S. (2011) Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal. J Orthop Res. 29(3):375-9

  14. Ghosal K, Pimplikar SW. (2011) Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice. Neurobiol Aging 32(12):2320.e1-9

  15. Alter BJ, Zhao C, Karim F, Landreth GE, Gereau RW 4th. (2010) Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci. 30(34):11537-47.

  16. Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC. (2010) Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One 4(12):e8283.

  17. Dumitriu B, Bhattaram P, Dy P, Huang Y, Quayum N, Jensen J, Lefebvre V.(2010) Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS One 5(8):e12088.

  18. Thein DC, Thalhammer JM, Hartwig AC, Crenshaw EB 3rd, Lefebvre V, Wegner M, Sock E (2010) The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. J Neurochem 115(1):131-41

  19. Ghosal K, Stathopoulos A, Pimplikar SW. (2010) APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS One 5(7):e11866

  20. Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S and Deneris ES. 2010. Pet-1 is required across different stages of life to regulate serotonergic function. Nature Neurosci 13(10):1190-8
    • The Deneris laboratory had previously shown that the Pet-1 transcription factor is required for the development of the serotonerigic system of the CNS. With inducible tissue-specific knockouts of Pet-1 they show that Pet-1 is required throughout life in serotonergic neurons.

  21. Dy P, Smits P, Silvester A, Penzo-Mendez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V. 2010 Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol. 341(2):346-59

  22. Hawthorne AL, Wylie CJ, Landmesser LT, Deneris ES, Silver J. Serotonergic neurons migrate radially through the neuroepithelium by dynamin-mediated somal translocation. J Neurosci. 2010 30(2):420-30.

  23. Wylie CJ, Hendricks TJ, Zhang B, Wang L, Lu P, Leahy P, Fox S, Maeno H, Deneris ES. Distinct transcriptomes define rostral and caudal serotonin neurons. J Neurosci. 2010 30(2):670-84.

  24. Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Neurogenetics. 2010 11:53-71

  25. Mack JA and Maytin EV. 2010 Persistent Inflammation and Angiogenesis during Wound Healing in K14-Directed Hoxb13 Transgenic Mice. J Invest Dermatol. 130(3):856-65

2009
  1. Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO and Roth BL. 2009 Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors. Neuron 63(1):27-39
    • The Roth lab developed transgenic mice in which activity of specific neuronal populations can be increased by a peripherally administered ligand. This approach is a powerful new tool to study mammalian brain function.

  2. Kawanami A, Matsushita T, Chan YY, Murakami S. Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum. Biochem Biophys Res Commun. 2009 386(3):477-82

  3. Braz JM, Enquist LW, Basbaum AI. (2009) Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing. J Comp Neurol. 514(2):145-60.

  4. Hodges MR, Wehner M, Aungst J, Smith JC, Richerson GB (2009) Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J Neurosci. 29(33):10341-9.

  5. Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL. (2009) Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A. 106(51):21966-71.

  6. Soler DC, Kadunganattil S, Ramdas S, Myers K, Roca J, Slaughter T, Pilder SH, and Vijayaraghavan S 2009 Expression of Transgenic PPP1CC2 in the Testis of Ppp1cc-Null Mice Rescues Spermatid Viability and Spermiation but Does Not Restore Normal Sperm Tail Ultrastructure, Sperm Motility, or Fertility Biol Reprod 81(2):343-52

  7. Mailankot M, Staniszewska MM, Butler H, Caprara MH, Howell S, Wang B, Doller C, Reneker LW, Nagaraj RH. 2009 Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. Lab Invest. 89(5):498-512

  8. Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. 2009 Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet. 18(8):1395-404

  9. Cheng L, Pilder S, Nairn AC, Ramdas S, Vijayaraghavan S. 2009 PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related. PLoS One. 4(3):e4861

  10. Li H, Wang D, Singh LS, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y. 2009 Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705.

  11. Walker MP, Tian L, Matera AG. 2009 Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. PLoS One. 4(7):e6171.

  12. Matsushita T, Wilcox WR, Chan YY, Kawanami A, Bükülmez H, Balmes G, Krejci P, Mekikian PB, Otani K, Yamaura I, Warman ML, Givol D, Murakami S. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet. 2009 18(2):227-240

  13. Zhang T, Yong SL, Drinko JK, Popovic ZB, Shryock JC, Belardinelli L, Wang QK. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. Int J Cardiol. 2009

  14. Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW. 2009 Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci U S A. 106(43):18367-72

  15. Qing Li, Danping Huang, Kristine Nacion, Hong Bu and Feng Lin Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis Mol Immunol. 2009 46(15):2885-91.

  16. Takehiko Matsushita, Yuk Yu Chan, Aya Kawanami, Gener Balmes, Gary E. Landreth, and Shunichi Murakami ERK1 and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis Mol Cell Biol. 2009 29(21):5843-57

  17. Bliss SP; Miller A; Navratil AM; Xie J; McDonough SP; Fisher PJ; Landreth GE; Roberson MS, ERK signaling in the pituitary is required for female but not male fertility., Mol Endocrinol 2009 Jul;23(7):1092-101

  18. Nakamura Y, Cui Y, Fernando C, Kutz WE, Warman ML. Normal growth and development in mice over-expressing the CCN family member WISP3. J Cell Commun Signal. 2009 3(2):105-13

  19. Hu Y, Lu X, Zhou G, Barnes EL, Luo G. Recql5 Plays an Important Role in DNA Replication and Cell Survival Following Camptothecin Treatment. Mol Biol Cell. 2009 (1):114-23

2008
  1. Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci U S A. 2008 105(44):17115-20

  2. Lerch-Haner JK, Frierson D, Crawford LK, Beck SG, Deneris ES. Serotonergic transcriptional programming determines maternal behavior and offspring survival. Nat Neurosci. 2008 (9):1001-3.
    • The Deneris lab investigated the maternal behavior of mice mutant for Pet1. These mice are deficient in brain serotonin neurons. They used different BAC transgenes expressing the human gene at different levels to rescue maternal behavior to different degrees.

  3. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 47(50):13296-307.

  4. Ogba N, Chaplin LJ, Doughman YQ, Fujinaga K, Montano MM. HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res. 2008 68(17):7015-24.

  5. Hodges MR, Richerson GB (2008) Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons. Respir Physiol Neurobiol. 164(3):350-7

  6. Braz JM, Basbaum AI. (2008) Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits. J Comp Neurol. 507(6):1990-2003.

  7. Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N, Zhou Q, Ward NL, Watanabe M. Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 102(4):415-22.

  8. Krueger KC, Deneris ES. Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors. J Neurosci. 2008 28(48):12748-58.

  9. Sutton AL, Zhang X, Dowd DR, Kharode YP, Komm BS, Macdonald PN. Semaphorin 3B Is a 1,25-Dihydroxyvitamin D3-Induced Gene in Osteoblasts that Promotes Osteoclastogenesis and Induces Osteopenia in Mice. Molecular Endocrinology 2008 22 (6): 1370-1381

  10. Dai JX, Han HL, Tian M, Cao J, Xiu JB, Song NN, Huang Y, Xu TL, Ding YQ, Xu L. (2008) Enhanced contextual fear memory in central serotonin-deficient mice. Proc Natl Acad Sci U S A. 105(33):11981-6

  11. Hodges CA, Cotton CU, Palmert MR, Drumm ML. Generation of a conditional null allele for Cftr in mice. Genesis. 2008 46(10):546-52.

  12. Hanson RW, Hakimi P. (2008) Born to run; the story of the PEPCK-Cmus mouse. Biochimie. 90(6):838-42

  13. Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD, Saitta SC, Landreth GE. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 28(27):6983-95.

  14. Merkulov S, Zhang WM, Komar AA, Schmaier AH, Barnes E, Zhou Y, Lu X, Iwaki T, Castellino FJ, Luo G, McCrae KR. Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood. 2008 111(3):1274-81.

  15. Huang QQ, Feng HZ, Liu J, Du J, Stull LB, Moravec CS, Huang X, Jin JP. Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function. Am J Physiol Cell Physiol. 2008 294(1):C213-22.

  16. Yang X, Zhou Y, Barcarse EA, O'Gorman S. Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol. 2008 314(1):171-88.

  17. Dy, P., Y. Han, and V. Lefebvre. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46:294-299

  18. Han Y, Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol. 2008 28(16):4999-5013

  19. Mailankot M, Smith D, Howell S, Wang B, Jacobberger JW, Stefan T, Nagaraj RH. Cell cycle arrest by kynurenine in lens epithelial cells. Invest Ophthalmol Vis Sci. 2008 49(12):5466-75

  20. Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK, O'Gorman S. Pbx3 is required for normal locomotion and dorsal horn development. Dev Biol. 2008 314(1):23-39

2007
  1. Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 2007 21(23):3073-84.
    • The Luo laboratory demonstrated that mice mutant for Recql5 are susceptible to cancer, and determined the mechanism by which Recql5 suppresses homologous recombination.

  2. Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007 282(45):32844-55.
    • The Hanson laboratory showed that overexpression of PEPCK in muscle dramatically changes energy metabolism in mice, resulting in leaner, more athletic mice. While these mice made a splash in the popular press for their athletic prowess, they will be important tools in understanding the links between metabolism, energy expenditure and cancer.
    • BBC News Story

  3. Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 46(28):8350-9.

  4. Penzo-Mendez A, Dy P, Pallavi B, Lefebvre V. Generation of mice harboring a Sox4 conditional null allele. Genesis. 2007 45(12):776-80.

  5. Zhao ZQ, Chiechio S, Sun YG, Zhang KH, Zhao CS, Scott M, Johnson RL, Deneris ES, Renner KJ, Gereau RW 4th, Chen ZF. (2007) Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci. 27(22):6045-53.

  6. Zhao ZQ, Gao YJ, Sun YG, Zhao CS, Gereau RW 4th, Chen ZF. (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. Proc Natl Acad Sci U S A. 104(36):14519-24.

  7. Johnson MT, Freeman EA, Gardner DK, Hunt PA. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod. 2007 77(1):2-8.

  8. Zhang T, Yong SL, Tian XL, Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochem Biophys Res Commun. 2007 355(2):444-50

  9. Jenkins MW, Patel P, Deng H, Montano MM, Watanabe M, Rollins AM. Phenotyping transgenic embryonic murine hearts using optical coherence tomography. Appl Opt. 2007 46(10):1776-81.

  10. Wu L, Archacki SR, Zhang T, Wang QK. Induction of high STAT1 expression in transgenic mice with LQTS and heart failure. Biochem Biophys Res Commun. 2007 358(2):449-54

2006
  1. Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW 4th, Johnson RL, Deneris ES, Chen ZF. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 26(49):12781-8.

  2. Xu X, Scott MM, Deneris ES. Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes. Mol Cell Biol. 2006 (15):5636-49
    • The Deneris lab used recombineered PAC transgenes to deduce the regulatory logic of cis-acting sequences in the nicotinic receptor gene cluster, demonstrating that there are shared regulatory elements.

  3. Jiang S, Xia D, Samols D. Expression of rabbit C-reactive protein in transgenic mice inhibits development of antigen-induced arthritis. Scand J Rheumatol. 2006 35(5):351-5.

  4. LaFauci G, Carp RI, Meeker HC, Ye X, Kim JI, Natelli M, Cedeno M, Petersen RB, Kascsak R, Rubenstein R. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. J Gen Virol. 2006 87(Pt 12):3773-80.

  5. Crish JF, Gopalakrishnan R, Bone F, Gilliam AC, Eckert RL. The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol. 2006 126(2):305-14.

  6. Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006 281(33):23698-711

  7. Basu A, DuBois G, Haldar S. Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. Front Biosci. 2006 11:1508-21

2005
  1. Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 435(7040):360-4.
    • The Ter mutation in mice causes germ cell loss and testicular germ cell tumors. The characterization of the Ter phenotype and the identification of Dnd as the gene mutant in Ter by the Nadeau and Matin labs was supported by services provided by the core. Transgenic mice expressing Green Fluorescent Protein from a germ cell specific promoter (Oct4-GFP) constructed by the facility demonstrated that germ cells are fewer in the Ter mutants. Dnd was identified positively as the gene mutant in Ter by complementation of germ cell numbers with a Dnd transgene introduced into mice by the facility.

  2. Scott MM, Wylie CJ, Lerch JK, Murphy R, Lobur K, Herlitze S, Jiang W, Conlon RA, Strowbridge BW, Deneris ES. A genetic approach to access serotonin neurons for in vivo and in vitro studies. Proc Natl Acad Sci U S A. 2005 102(45):16472-7.
    • BAC transgene constructs were used by the Deneris lab to rescue the Pet1 mutant phenotype, and to express EYFP and Cre in serotonergic neurons of the brain. These experiments generated genetic reagents for the dissection of the function of brain-derived serotonin and beautifly illustrate the power of BAC transgenes.

  3. Ryan KA, Pimplikar SW Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 171(2):327-35

  4. Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 2005 30(4):624-9.

  5. Hakimi P, Johnson MT, Yang J, Lepage DF, Conlon RA, Kalhan SC, Reshef L, Tilghman SM, Hanson RW. Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab (Lond). 2005 2:33

  6. Nethery DE, Moore BB, Minowada G, Carroll J, Faress JA, Kern JA. Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. J Appl Physiol. 2005 99(1):298-307

  7. Black S, Wilson A, Samols D. An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. J Immunol. 2005 175(2):1192-6.

  8. O'Gorman S. Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice. Dev Dyn. 2005 234(1):124-31.

  9. Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G. Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol. 2005 25(9):3431-42

  10. Chan SA, Polo-Parada L, Landmesser LT, Smith C. Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice. J Neurophysiol. 2005 94(2):1037-47

  11. Scott MM, Krueger KC, Deneris ES A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. J Neurosci. 2005 25(10):2628-36

  12. Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, Luo G Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet. 2005 14(6):813-25

  13. Kutz WE, Gong Y, Warman ML. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 25(1):414-21

  14. Adhikary G, Crish JF, Bone F, Gopalakrishnan R, Lass J, Eckert RL. An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo. Invest Ophthalmol Vis Sci 2005 46:1219-1227.

  15. Adhikary G, Crish JF, Gopalakrishnan R, Bone F, Eckert RL. Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors. Invest Ophthalmol Vis Sci 2005 46: 3109-3120.

  16. Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, Forsthuber TG. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol. 2005 175(4):2374-80

  17. Clement-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssiere B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A. 2005 102(48):17406-11

2004
  1. Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004 165:145-154

  2. • The Lemmon lab used L1 knockout mice to study the role of this homophilic adhesion molecule in brain development.

  3. Nosek TM, Brotto MA, Jin JP. Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis. Arch Biochem Biophys. 2004 430(2):178-84.

  4. Polo-Parada L, Bose CM, Plattner F, Landmesser LT. Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice. J Neurosci. 2004 24(8):1852-64.

  5. Adhikary G, Crish J, Lass J, Eckert RL. Regulation of involucrin expression in normal human corneal epithelial cells: a role for activator protein one. Invest Ophthalmol Vis Sci 2004 45:1080-1087

  6. Balasubramanian S, Eckert RL. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. 2004 J Biol Chem 279:24007-24014